Differential Diagnosis
DDx Strength: Weak
leflunomide, Multiple skin lesions Add or remove findings

Exanthematous drug eruption

2/2
Exanthematous drug eruptionExanthematous drug eruption

Keratoacanthoma

2/2
KeratoacanthomaKeratoacanthoma

Drug-induced hepatotoxicity

2/2
Drug-induced hepatotoxicity

Subacute cutaneous lupus erythematosus

2/2
Subacute cutaneous lupus erythematosusSubacute cutaneous lupus erythematosus

Vasculitis

2/2
VasculitisVasculitis

Drug-induced photosensitive reaction

2/2
Drug-induced photosensitive reactionDrug-induced photosensitive reaction

Lichenoid drug eruption

2/2
Lichenoid drug eruptionLichenoid drug eruption

Erythema multiforme

2/2
Erythema multiformeErythema multiforme

Erythroderma

2/2
ErythrodermaErythroderma

Pruritus without rash

2/2
Pruritus without rashPruritus without rash

Drug-induced hypersensitivity syndrome

2/2
Drug-induced hypersensitivity syndromeDrug-induced hypersensitivity syndrome

Drug-induced skin ulcers

2/2
Drug-induced skin ulcersDrug-induced skin ulcers

Toxic epidermal necrolysis

2/2
Toxic epidermal necrolysisToxic epidermal necrolysis

Alopecia areata

2/2
Alopecia areataAlopecia areata

Bullous drug eruption

2/2
Bullous drug eruptionBullous drug eruption

Histoplasmosis

2/2
HistoplasmosisHistoplasmosis

Hyperhidrosis

2/2
HyperhidrosisHyperhidrosis

Acquired pancytopenia

2/2
Acquired pancytopeniaAcquired pancytopenia

Aplastic anemia

2/2
Aplastic anemiaAplastic anemia

Non-AIDS Kaposi sarcoma

2/2
Non-AIDS Kaposi sarcomaNon-AIDS Kaposi sarcoma

Drug-induced diarrhea

1/2
Drug-induced diarrhea

Drug-induced dyspepsia

1/2
Drug-induced dyspepsia

Drug-induced nausea or vomiting

1/2
Drug-induced nausea or vomiting

Drug-induced abdominal pain

1/2
Drug-induced abdominal pain

Drug-induced cough

1/2
Drug-induced cough

Drug-induced alopecia

1/2
Drug-induced alopeciaDrug-induced alopecia

Peripheral neuropathy

1/2
Peripheral neuropathy

Drug-induced hypertension

1/2
Drug-induced hypertension

Drug-induced headache

1/2
Drug-induced headache

Pneumothorax

1/2
Pneumothorax

Drug-induced dysgeusia

1/2
Drug-induced dysgeusia

Drug-induced dyspnea

1/2
Drug-induced dyspnea

Drug-induced hypotension

1/2
Drug-induced hypotension

Drug-induced leukopenia

1/2
Drug-induced leukopenia

Drug-induced oral ulcer

1/2
Drug-induced oral ulcerDrug-induced oral ulcer

Drug-induced weight loss

1/2
Drug-induced weight loss

Gingival hyperplasia

1/2
Gingival hyperplasiaGingival hyperplasia

Hypocalcemia

1/2
Hypocalcemia

Acute interstitial pneumonia

1/2
Acute interstitial pneumoniaAcute interstitial pneumonia

Drug-induced hepatitis

1/2
Drug-induced hepatitis

Pulmonary artery hypertension

1/2
Pulmonary artery hypertension

Rhabdomyolysis

1/2
Rhabdomyolysis

Drug-induced leukocytosis

1/2
Drug-induced leukocytosis

Drug-induced movement disorders

1/2
Drug-induced movement disorders

Drug-induced weight gain

1/2
Drug-induced weight gain

Polymyositis

1/2
Polymyositis

Progressive multifocal leukoencephalopathy

1/2
Progressive multifocal leukoencephalopathy

Pulmonary hypertension

1/2
Pulmonary hypertension

Drug-induced anemia

1/2
Drug-induced anemia

Pulmonary alveolar proteinosis

1/2
Pulmonary alveolar proteinosis