Differential Diagnosis
DDx Strength: Excellent
Multiple skin lesions, Blanching patch, Lower leg, Round configuration, Tender skin lesion, Fever, Fatigue, Oral contraceptives, 30-39 year old Female Add or remove findings

Erythema nodosum

8/8
Erythema nodosumErythema nodosum

Panniculitis

7/8
PanniculitisPanniculitis

Cutaneous breast cancer

6/8
Cutaneous breast cancerCutaneous breast cancer

Cellulitis

6/8
CellulitisCellulitis

Deep vein thrombosis

6/8
Deep vein thrombosisDeep vein thrombosis

Erythema multiforme

6/8
Erythema multiformeErythema multiforme

Erysipelas

6/8
ErysipelasErysipelas

Lyme disease

6/8
Lyme diseaseLyme disease

Southern tick-associated rash illness

6/8
Southern tick-associated rash illnessSouthern tick-associated rash illness

Necrotizing fasciitis

6/8
Necrotizing fasciitisNecrotizing fasciitis

Multicentric reticulohistiocytosis

6/8
Multicentric reticulohistiocytosisMulticentric reticulohistiocytosis

Herpes zoster

5/8
Herpes zosterHerpes zoster

Drug-induced lupus erythematosus

5/8
Drug-induced lupus erythematosusDrug-induced lupus erythematosus

Fixed drug eruption

5/8
Fixed drug eruptionFixed drug eruption

Sjögren syndrome

5/8
Sjögren syndromeSjögren syndrome

Bacterial sepsis

5/8
Bacterial sepsisBacterial sepsis

Acute febrile neutrophilic dermatosis

5/8
Acute febrile neutrophilic dermatosisAcute febrile neutrophilic dermatosis

Thrombotic thrombocytopenic purpura

5/8
Thrombotic thrombocytopenic purpuraThrombotic thrombocytopenic purpura

Cryofibrinogenemia

5/8
CryofibrinogenemiaCryofibrinogenemia

Ulcerative colitis

5/8
Ulcerative colitisUlcerative colitis

Eosinophilic granulomatosis with polyangiitis

5/8
Eosinophilic granulomatosis with polyangiitisEosinophilic granulomatosis with polyangiitis

Disseminated Fusarium infection

5/8
Disseminated Fusarium infectionDisseminated Fusarium infection

Human Anaplasmataceae infection

5/8
Human Anaplasmataceae infectionHuman Anaplasmataceae infection

Serum sickness

5/8
Serum sicknessSerum sickness

Recluse spider envenomation

5/8
Recluse spider envenomationRecluse spider envenomation

Eosinophilic cellulitis

5/8
Eosinophilic cellulitisEosinophilic cellulitis

Takayasu arteritis

5/8
Takayasu arteritisTakayasu arteritis

Immunoglobulin A vasculitis

5/8
Immunoglobulin A vasculitisImmunoglobulin A vasculitis

Majeed syndrome

5/8
Majeed syndrome

Livedo reticularis

4/8
Livedo reticularisLivedo reticularis

Exanthematous drug eruption

4/8
Exanthematous drug eruptionExanthematous drug eruption

Nummular dermatitis

4/8
Nummular dermatitisNummular dermatitis

Allergic contact dermatitis

4/8
Allergic contact dermatitisAllergic contact dermatitis

Arthropod bite or sting

4/8
Arthropod bite or stingArthropod bite or sting

CA-MRSA skin infection

4/8
CA-MRSA skin infectionCA-MRSA skin infection

Poison ivy - oak - sumac dermatitis

4/8
Poison ivy - oak - sumac dermatitisPoison ivy - oak - sumac dermatitis

Subacute cutaneous lupus erythematosus

4/8
Subacute cutaneous lupus erythematosusSubacute cutaneous lupus erythematosus

Drug-induced phototoxic reaction

4/8
Drug-induced phototoxic reactionDrug-induced phototoxic reaction

Osteomyelitis

4/8
OsteomyelitisOsteomyelitis

Systemic lupus erythematosus

4/8
Systemic lupus erythematosusSystemic lupus erythematosus

Cocaine levamisole toxicity

4/8
Cocaine levamisole toxicityCocaine levamisole toxicity

Lymphangitis

4/8
LymphangitisLymphangitis

Non-Hodgkin lymphoma

4/8
Non-Hodgkin lymphomaNon-Hodgkin lymphoma

Rheumatoid vasculitis

4/8
Rheumatoid vasculitisRheumatoid vasculitis

Rocky Mountain spotted fever

4/8
Rocky Mountain spotted feverRocky Mountain spotted fever

Sarcoidosis

4/8
SarcoidosisSarcoidosis

Cutaneous T-cell lymphoma

4/8
Cutaneous T-cell lymphomaCutaneous T-cell lymphoma

Leukocytoclastic vasculitis

4/8
Leukocytoclastic vasculitisLeukocytoclastic vasculitis

Urticarial vasculitis

4/8
Urticarial vasculitisUrticarial vasculitis

Vasculitis

4/8
VasculitisVasculitis

Drug-induced hepatotoxicity

4/8
Drug-induced hepatotoxicity

Crohn disease

4/8
Crohn diseaseCrohn disease

Antiphospholipid antibody syndrome

4/8
Antiphospholipid antibody syndromeAntiphospholipid antibody syndrome

Pustular psoriasis

4/8
Pustular psoriasisPustular psoriasis

Stevens-Johnson syndrome

4/8
Stevens-Johnson syndromeStevens-Johnson syndrome

Mycobacterium avium-intracellulare infection

4/8
Mycobacterium avium-intracellulare infectionMycobacterium avium-intracellulare infection

West Nile virus

4/8
West Nile virusWest Nile virus

Cutaneous B-cell lymphoma

4/8
Cutaneous B-cell lymphomaCutaneous B-cell lymphoma

Kikuchi-Fujimoto disease

4/8
Kikuchi-Fujimoto diseaseKikuchi-Fujimoto disease

Secondary syphilis

4/8
Secondary syphilisSecondary syphilis

Vibrio vulnificus infection

4/8
Vibrio vulnificus infectionVibrio vulnificus infection

Acute meningococcemia

4/8
Acute meningococcemiaAcute meningococcemia

Anti-TNF-alpha-induced eruptions

4/8
Anti-TNF-alpha-induced eruptions

Atypical mycobacterial infection

4/8
Atypical mycobacterial infectionAtypical mycobacterial infection

Bacillary angiomatosis

4/8
Bacillary angiomatosisBacillary angiomatosis

Blastomycosis

4/8
BlastomycosisBlastomycosis

Bowel-associated dermatosis-arthritis syndrome

4/8
Bowel-associated dermatosis-arthritis syndromeBowel-associated dermatosis-arthritis syndrome

Brucellosis

4/8
BrucellosisBrucellosis

Capnocytophaga canimorsus sepsis

4/8
Capnocytophaga canimorsus sepsis

Coccidioidomycosis

4/8
CoccidioidomycosisCoccidioidomycosis

Erythema infectiosum

4/8
Erythema infectiosumErythema infectiosum

Histoplasmosis

4/8
HistoplasmosisHistoplasmosis

Mixed essential cryoglobulinemia

4/8
Mixed essential cryoglobulinemia

Mucormycosis

4/8
MucormycosisMucormycosis

Neutrophilic eccrine hidradenitis

4/8
Neutrophilic eccrine hidradenitisNeutrophilic eccrine hidradenitis

Nodular vasculitis

4/8
Nodular vasculitisNodular vasculitis

Paederus dermatitis

4/8
Paederus dermatitisPaederus dermatitis

Polyarteritis nodosa

4/8
Polyarteritis nodosaPolyarteritis nodosa

Psittacosis

4/8
Psittacosis

Queensland tick typhus

4/8
Queensland tick typhusQueensland tick typhus

South American bartonellosis

4/8
South American bartonellosisSouth American bartonellosis

Tularemia

4/8
TularemiaTularemia

Typhoid fever

4/8
Typhoid feverTyphoid fever

Botryomycosis

4/8
BotryomycosisBotryomycosis

Caterpillar dermatitis

4/8
Caterpillar dermatitisCaterpillar dermatitis

Dermatomyositis

4/8
DermatomyositisDermatomyositis

Disseminated herpes zoster

4/8
Disseminated herpes zoster

Papular-purpuric gloves and socks syndrome

4/8
Papular-purpuric gloves and socks syndromePapular-purpuric gloves and socks syndrome

Polymyalgia rheumatica

4/8
Polymyalgia rheumaticaPolymyalgia rheumatica

Pseudolymphoma

4/8
PseudolymphomaPseudolymphoma

Staphylococcal scalded skin syndrome

4/8
Staphylococcal scalded skin syndromeStaphylococcal scalded skin syndrome

Toxic epidermal necrolysis

4/8
Toxic epidermal necrolysisToxic epidermal necrolysis

Atrial myxoma

4/8
Atrial myxomaAtrial myxoma

Immune-related adverse effects

4/8
Immune-related adverse effects

Kawasaki disease

4/8
Kawasaki diseaseKawasaki disease

Lymphomatoid granulomatosis

4/8
Lymphomatoid granulomatosisLymphomatoid granulomatosis

Scurvy

4/8
ScurvyScurvy

TNF receptor-associated periodic syndrome

4/8
TNF receptor-associated periodic syndromeTNF receptor-associated periodic syndrome

Familial Mediterranean fever

4/8
Familial Mediterranean feverFamilial Mediterranean fever

Glanders

4/8
GlandersGlanders

Palmar-plantar eccrine hidradenitis

4/8
Palmar-plantar eccrine hidradenitisPalmar-plantar eccrine hidradenitis

Pancreatic panniculitis

4/8
Pancreatic panniculitisPancreatic panniculitis

Purpura fulminans

4/8
Purpura fulminansPurpura fulminans

Tanapox

4/8
TanapoxTanapox

Zika virus infection

4/8
Zika virus infectionZika virus infection

Cutaneous nocardiosis

4/8
Cutaneous nocardiosisCutaneous nocardiosis

Granulomatosis with polyangiitis

4/8
Granulomatosis with polyangiitisGranulomatosis with polyangiitis

Loiasis

4/8
LoiasisLoiasis

Multiple myeloma

4/8
Multiple myelomaMultiple myeloma

PAPA syndrome

4/8
PAPA syndrome

Sclerodermatomyositis

4/8
SclerodermatomyositisSclerodermatomyositis

MAGIC syndrome

4/8
MAGIC syndrome

Yaws

4/8
YawsYaws

CANDLE syndrome

4/8
CANDLE syndrome

Hydroa vacciniforme

4/8
Hydroa vacciniformeHydroa vacciniforme

Phakomatosis pigmentovascularis

4/8
Phakomatosis pigmentovascularis

Proteasome-associated autoinflammatory syndromes

4/8
Proteasome-associated autoinflammatory syndromes