Differential Diagnosis
DDx Strength: Weak
Opioid analgesic, Multiple skin lesions Add or remove findings

Exanthematous drug eruption

2/2
Exanthematous drug eruptionExanthematous drug eruption

Allergic contact dermatitis

2/2
Allergic contact dermatitisAllergic contact dermatitis

Urticaria

2/2
UrticariaUrticaria

Anaphylaxis

2/2
Anaphylaxis

Candidiasis

2/2
CandidiasisCandidiasis

Cheilitis

2/2
CheilitisCheilitis

Livedo reticularis

2/2
Livedo reticularisLivedo reticularis

Neurotic excoriations

2/2
Neurotic excoriationsNeurotic excoriations

Pruritus without rash

2/2
Pruritus without rashPruritus without rash

Drug-induced hepatotoxicity

2/2
Drug-induced hepatotoxicity

Skin popping substance abuse

2/2
Skin popping substance abuseSkin popping substance abuse

Fixed drug eruption

2/2
Fixed drug eruptionFixed drug eruption

Angioedema

2/2
AngioedemaAngioedema

Erythroderma

2/2
ErythrodermaErythroderma

Osteomyelitis

2/2
OsteomyelitisOsteomyelitis

Erythema multiforme

2/2
Erythema multiformeErythema multiforme

Hyperhidrosis

2/2
HyperhidrosisHyperhidrosis

Acute generalized exanthematous pustulosis

2/2
Acute generalized exanthematous pustulosisAcute generalized exanthematous pustulosis

Drug-induced skin ulcers

2/2
Drug-induced skin ulcersDrug-induced skin ulcers

Systemic contact dermatitis

2/2
Systemic contact dermatitisSystemic contact dermatitis

Stevens-Johnson syndrome

2/2
Stevens-Johnson syndromeStevens-Johnson syndrome

Symmetric drug-related intertriginous and flexural exanthema

2/2
Symmetric drug-related intertriginous and flexural exanthema

Toxic epidermal necrolysis

2/2
Toxic epidermal necrolysisToxic epidermal necrolysis

Drug-induced hypersensitivity syndrome

2/2
Drug-induced hypersensitivity syndromeDrug-induced hypersensitivity syndrome

Adrenal crisis

2/2
Adrenal crisis

Baboon syndrome

2/2
Baboon syndromeBaboon syndrome

Coma bullae

2/2
Coma bullaeComa bullae

Contact urticaria

2/2
Contact urticariaContact urticaria

Morphea

2/2
MorpheaMorphea

Pemphigus vegetans

2/2
Pemphigus vegetansPemphigus vegetans

Pemphigus vulgaris

2/2
Pemphigus vulgarisPemphigus vulgaris

Polyarteritis nodosa

2/2
Polyarteritis nodosaPolyarteritis nodosa

Thrombotic thrombocytopenic purpura

2/2
Thrombotic thrombocytopenic purpuraThrombotic thrombocytopenic purpura

Cutaneous anthrax

2/2
Cutaneous anthraxCutaneous anthrax

Acquired pancytopenia

2/2
Acquired pancytopeniaAcquired pancytopenia

Drug-induced sclerodermoid reactions

2/2
Drug-induced sclerodermoid reactions

Fournier gangrene

2/2
Fournier gangreneFournier gangrene

Urticaria pigmentosa

2/2
Urticaria pigmentosaUrticaria pigmentosa

Arsenic poisoning

2/2
Arsenic poisoningArsenic poisoning

Henoch-Schönlein purpura

2/2
Henoch-Schönlein purpuraHenoch-Schönlein purpura

Drug-induced nausea or vomiting

1/2
Drug-induced nausea or vomiting

Opioid toxicity

1/2
Opioid toxicity

Drug-induced abdominal pain

1/2
Drug-induced abdominal pain

Drug-induced diarrhea

1/2
Drug-induced diarrhea

Sensorineural deafness

1/2
Sensorineural deafness

Drug-induced dyspepsia

1/2
Drug-induced dyspepsia

Drug-induced cough

1/2
Drug-induced cough

Depressive disorders

1/2
Depressive disorders

Drug-induced syncope

1/2
Drug-induced syncope

Insomnia

1/2
Insomnia

Orthostatic hypotension

1/2
Orthostatic hypotension

Gastroesophageal reflux disease

1/2
Gastroesophageal reflux disease

Myocardial ischemia

1/2
Myocardial ischemia

Dehydration

1/2
DehydrationDehydration

Myocardial infarction

1/2
Myocardial infarction

Urinary tract infection

1/2
Urinary tract infection

Coronary artery disease

1/2
Coronary artery disease

Hydronephrosis

1/2
HydronephrosisHydronephrosis

Migraine headache

1/2
Migraine headache

Transverse myelitis

1/2
Transverse myelitis

Ventricular tachycardia

1/2
Ventricular tachycardia

Chronic kidney disease

1/2
Chronic kidney diseaseChronic kidney disease

Drug-induced polyneuropathy

1/2
Drug-induced polyneuropathy

Parkinsonism

1/2
Parkinsonism

Drug-induced somnolence

1/2
Drug-induced somnolence

Drug-induced constipation

1/2
Drug-induced constipation

Drug-induced hypotension

1/2
Drug-induced hypotension

Drug-induced headache

1/2
Drug-induced headache

Opioid withdrawal syndrome

1/2
Opioid withdrawal syndrome

Drug-induced diaphoresis

1/2
Drug-induced diaphoresis

Prolonged QT interval

1/2
Prolonged QT interval

Opioid use disorder

1/2
Opioid use disorder

Seizure

1/2
Seizure

Drug-induced fatigue

1/2
Drug-induced fatigue

Serotonin syndrome

1/2
Serotonin syndrome

Drug-induced dizziness

1/2
Drug-induced dizziness

Drug-induced hypertension

1/2
Drug-induced hypertension

Drug-induced dyspnea

1/2
Drug-induced dyspnea

Hypoglycemia

1/2
Hypoglycemia

Vertigo

1/2
Vertigo

Drug-induced anorexia

1/2
Drug-induced anorexia

Drug-induced arthralgia

1/2
Drug-induced arthralgia

Pulmonary edema

1/2
Pulmonary edema

Respiratory acidosis

1/2
Respiratory acidosis

Delirium

1/2
Delirium

Drug-induced anxiety

1/2
Drug-induced anxiety

Acute kidney injury

1/2
Acute kidney injury

Drug-induced erectile dysfunction

1/2
Drug-induced erectile dysfunction

Medication overuse headache

1/2
Medication overuse headache

Substance-induced sexual dysfunction

1/2
Substance-induced sexual dysfunction

Acute pancreatitis

1/2
Acute pancreatitisAcute pancreatitis

Caries

1/2
Caries

Drug-induced palpitations

1/2
Drug-induced palpitations

Drug-induced stroke

1/2
Drug-induced stroke

Gastroparesis

1/2
Gastroparesis

Atrial fibrillation

1/2
Atrial fibrillation

Drug-induced epistaxis

1/2
Drug-induced epistaxis

Drug-induced leukopenia

1/2
Drug-induced leukopenia

Ocular drug reaction

1/2
Ocular drug reaction

Respiratory failure

1/2
Respiratory failure

Sinus bradycardia

1/2
Sinus bradycardia

Drug-induced myopathies

1/2
Drug-induced myopathies

Drug-induced oral ulcer

1/2
Drug-induced oral ulcerDrug-induced oral ulcer

Fecal impaction

1/2
Fecal impaction

Syndrome of inappropriate antidiuretic hormone

1/2
Syndrome of inappropriate antidiuretic hormone

Ventricular fibrillation

1/2
Ventricular fibrillation

Acute interstitial nephritis

1/2
Acute interstitial nephritis

Bladder cancer

1/2
Bladder cancerBladder cancer

Brugada syndrome

1/2
Brugada syndrome

Drug-induced akathisia

1/2
Drug-induced akathisia

Drug-induced esophagitis

1/2
Drug-induced esophagitis

Drug-induced hematuria

1/2
Drug-induced hematuria

Drug-induced weight loss

1/2
Drug-induced weight loss

Focal segmental glomerulosclerosis

1/2
Focal segmental glomerulosclerosis

Gastric ulcer

1/2
Gastric ulcer

Hepatic encephalopathy

1/2
Hepatic encephalopathy

Hypocalcemia

1/2
Hypocalcemia

Peripheral neuropathy

1/2
Peripheral neuropathy

Pneumothorax

1/2
Pneumothorax

Renal papillary necrosis

1/2
Renal papillary necrosis

Secondary adrenal insufficiency

1/2
Secondary adrenal insufficiency

Drug-induced dysgeusia

1/2
Drug-induced dysgeusia

Torsades de pointes

1/2
Torsades de pointes

Rhabdomyolysis

1/2
Rhabdomyolysis

Drug-induced movement disorders

1/2
Drug-induced movement disorders

Drug-induced weakness

1/2
Drug-induced weakness

Drug-induced ototoxicity

1/2
Drug-induced ototoxicity

Drug-induced flushing reaction

1/2
Drug-induced flushing reaction

Drug-induced fever

1/2
Drug-induced fever

Drug-induced muscle spasm

1/2
Drug-induced muscle spasm

Acute liver failure

1/2
Acute liver failure

Drug-induced menstrual changes

1/2
Drug-induced menstrual changes

Hypothermia

1/2
Hypothermia

Lead poisoning

1/2
Lead poisoningLead poisoning

Drug-induced psychosis

1/2
Drug-induced psychosis

Horner syndrome

1/2
Horner syndrome

Acute eosinophilic pneumonia

1/2
Acute eosinophilic pneumoniaAcute eosinophilic pneumonia

Acute respiratory distress syndrome

1/2
Acute respiratory distress syndromeAcute respiratory distress syndrome

Drug-induced dysphagia

1/2
Drug-induced dysphagia

Drug-induced paresthesia

1/2
Drug-induced paresthesia

Galactorrhea

1/2
GalactorrheaGalactorrhea

Hypogonadotropic hypogonadism

1/2
Hypogonadotropic hypogonadism

Hyponatremia

1/2
Hyponatremia

Ileus

1/2
Ileus

Takotsubo cardiomyopathy

1/2
Takotsubo cardiomyopathy

AA amyloidosis

1/2
AA amyloidosis

Bronchiectasis

1/2
Bronchiectasis

Drug-induced hepatitis

1/2
Drug-induced hepatitis

Hemolytic anemia

1/2
Hemolytic anemia

Hyperprolactinemia

1/2
Hyperprolactinemia

Proctitis

1/2
Proctitis

Acrocyanosis

1/2
AcrocyanosisAcrocyanosis

Acute interstitial pneumonia

1/2
Acute interstitial pneumoniaAcute interstitial pneumonia

Bowel perforation

1/2
Bowel perforationBowel perforation

Cardiogenic shock

1/2
Cardiogenic shock

Drug-induced chest pain

1/2
Drug-induced chest pain

Drug-induced diabetes

1/2
Drug-induced diabetes

Drug-induced dystonia

1/2
Drug-induced dystonia

Drug-induced heart failure

1/2
Drug-induced heart failure

Drug-induced hyperlipasemia

1/2
Drug-induced hyperlipasemia

Drug-induced oral pigmentation

1/2
Drug-induced oral pigmentationDrug-induced oral pigmentation

Drug-induced weight gain

1/2
Drug-induced weight gain

Hypopituitarism

1/2
Hypopituitarism

Large bowel obstruction

1/2
Large bowel obstructionLarge bowel obstruction

Nephrotic syndrome

1/2
Nephrotic syndrome

Pericarditis

1/2
PericarditisPericarditis

Polymyositis

1/2
Polymyositis

Pulmonary hypertension

1/2
Pulmonary hypertension

Reversible posterior leukoencephalopathy syndrome

1/2
Reversible posterior leukoencephalopathy syndrome

Glomerulonephritis

1/2
Glomerulonephritis

Myelofibrosis

1/2
Myelofibrosis

Pulmonary artery hypertension

1/2
Pulmonary artery hypertension

Talc-associated lung disease

1/2
Talc-associated lung disease

Drug-induced anemia

1/2
Drug-induced anemia

Drug-induced hyperamylasemia

1/2
Drug-induced hyperamylasemia

Botulism

1/2
BotulismBotulism

Drug-induced amnesia

1/2
Drug-induced amnesia

Drug-induced jaundice

1/2
Drug-induced jaundiceDrug-induced jaundice