Purpura Fulminans

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Image of Purpura Fulminans

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D65 – Disseminated intravascular coagulation [defibrination syndrome]

13507004 – Purpura fulminans


Purpura fulminans is a severe, often fatal condition that usually follows a bacterial infection, commonly Neisseria meningitidis, and results in disseminated intravascular coagulation and skin necrosis. Though primarily seen in children, purpura fulminans can occur in patients of all ages. It is also associated with infection with pneumococci, the varicella zoster virus, the measles virus, staphylococci, and Group A beta-hemolytic streptococci. Acquired deficiencies of proteins C and S may contribute to the pathogenesis. Acute illness is manifest by a septic-appearing patient with high fever and rapid deterioration leading to hypotension and shock. There is progression from acral purpura to widespread ecchymoses and gangrene.

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