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Löfgren syndrome
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Löfgren syndrome

Contributors: Benjamin L. Mazer MD, MBA
Other Resources UpToDate PubMed

Synopsis

Löfgren syndrome is a constellation of symptoms that is nearly always suggestive of acute sarcoidosis. The primary symptoms are erythema nodosum and hilar lymphadenopathy. Arthritis, uveitis, and fever also frequently occur. Primary tuberculosis can rarely present with hilar lymphadenopathy and erythema nodosum. The simultaneous presence of all the typical features of Löfgren syndrome, however, is highly specific for sarcoidosis.

Löfgren syndrome predominantly occurs in female patients of Northern European descent. Unlike other manifestations of sarcoidosis, Löfgren syndrome usually resolves within 2 years and rarely relapses. NSAIDs are the typical treatment, with immunosuppression sometimes required.

Codes

ICD10CM:
D86.86 – Sarcoid arthropathy

SNOMEDCT:
238676008 – Lofgrens syndrome

Differential Diagnosis & Pitfalls

To perform a comparison, select diagnoses from the classic differential

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Best Tests

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References

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Last Updated:10/25/2015
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Löfgren syndrome
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A medical illustration showing key findings of Löfgren syndrome : Fever, Hilar lymphadenopathy, Malaise, Migrating polyarthralgia, Arthralgia
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