SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferences

Information for Patients

View all Images (25)

Erythema nodosum in Child
Other Resources UpToDate PubMed

Erythema nodosum in Child

Contributors: Andrina Mamo BS, Andrew Walls MD, Craig N. Burkhart MD, Dean Morrell MD, Susan Burgin MD
Other Resources UpToDate PubMed


Erythema nodosum (EN) is the most common type of septal panniculitis (inflammation of the subcutaneous fat) and results from a delayed hypersensitivity to various stimuli, such as bacterial and viral infections (most commonly Streptococcus and Epstein-Barr virus [EBV], respectively), medications, malignancies, inflammatory bowel disease (see Crohn disease, ulcerative colitis), fungal infections, and collagen vascular diseases. However, in 33%-50% of cases, no associations are found. A detailed list of etiologies is below.

The eruption persists for 3-6 weeks and spontaneously regresses without ulceration, scarring, or atrophy.

EN occurs in boys and girls in equal proportions before puberty (it rarely occurs before age 2); however, after puberty, females are more frequently affected, as in the adult population. Recurrences with reappearance of the precipitating factor(s) are reported.

More commonly associated infections:
Less common infectious associations:
Inflammatory etiologies:
Malignancy (especially leukemia)

  • Oral contraceptives, sulfonamides, penicillins, cephalosporins, macrolide antibiotics


L52 – Erythema nodosum

32861005 – Erythema nodosum

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

To perform a comparison, select diagnoses from the classic differential

Subscription Required

Best Tests

Subscription Required

Management Pearls

Subscription Required


Subscription Required

Drug Reaction Data

Subscription Required


Subscription Required

Last Reviewed:06/26/2022
Last Updated:07/02/2022
Copyright © 2024 VisualDx®. All rights reserved.
Patient Information for Erythema nodosum in Child
Contributors: Medical staff writer
Premium Feature
VisualDx Patient Handouts
Available in the Elite package
  • Improve treatment compliance
  • Reduce after-hours questions
  • Increase patient engagement and satisfaction
  • Written in clear, easy-to-understand language. No confusing jargon.
  • Available in English and Spanish
  • Print out or email directly to your patient
Copyright © 2024 VisualDx®. All rights reserved.
Erythema nodosum in Child
A medical illustration showing key findings of Erythema nodosum (Adult) : Arthralgia, Smooth nodules, Smooth plaques
Clinical image of Erythema nodosum - imageId=2299356. Click to open in gallery.  caption: 'Many erythematous and ecchymotic plaques of varying sizes on the lower legs.'
Many erythematous and ecchymotic plaques of varying sizes on the lower legs.
Copyright © 2024 VisualDx®. All rights reserved.