Symmetric drug-related intertriginous and flexural exanthema
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Synopsis
The latency period could range from hours to days after exposure. The pathogenesis is unknown. It is speculated that a T cell-mediated delayed-type hypersensitivity reaction may mitigate the eruption. Increased drug excretion on the skin folds, which have a high density of eccrine glands, could explain the distribution of the rash.
When the buttocks are predominantly affected, the diagnosis is also known as baboon syndrome, although nomenclature remains a challenge; the relationship between baboon syndrome and SDRIFE is still being evaluated.
Related topic: systemic contact dermatitis
Codes
L27.0 – Generalized skin eruption due to drugs and medicaments taken internally
SNOMEDCT:
238813009 – Drug exanthem
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Last Updated:04/08/2024