The acute form of gout presents as a painful, swollen, warm, and erythematous joint, usually monoarticular, with the most common joints affected being the first metatarsophalangeal joint, ankle, foot, and knee. The pain can be debilitating. Flares can last days to weeks if untreated and can become more severe and more frequent over time.
Chronic tophaceous gout presents most commonly involving the ear but can also affect other soft tissues, articular structures, bursas, or tendons. Smooth or multilobulated nodules can ulcerate, leading to extrusion of a chalk-like substance. Rarely, urate bullae may develop. In uncontrolled chronic gout, there may be frequent acute attacks that lead to destructive arthritis and joint deformity.
Men aged 40-50 are most commonly affected. Other risk factors include renal insufficiency, obesity, increased alcohol consumption, medications (eg, diuretics), lymphomas, leukemias, tumor lysis syndrome, and hemolysis as well as lead exposure (eg, from illegally distilled liquor, or "moonshine"; known colloquially as "saturnine gout").
M10.9 – Gout, unspecified
90560007 – Gout
Differential Diagnosis & Pitfalls
- Calcium pyrophosphate deposition disease (pseudogout)
- Septic arthritis
- Toxic synovitis
- Psoriatic arthritis
- Reactive arthritis
- Blistering distal dactylitis
Drug Reaction Data