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Melanocytic matricoma
Other Resources UpToDate PubMed

Melanocytic matricoma

Contributors: Hannah B. Kopelman DO, Susan Burgin MD
Other Resources UpToDate PubMed


Melanocytic matricoma is a rare, benign adnexal tumor that originates from the hair matrix. It is characterized by the presence of melanocytes and matrical cells within the tumor. It is more common in adults, and there is no significant difference in prevalence between sexes or races / ethnicities. Some authors believe it to be a variant of matricoma or pilomatricoma.

Clinically, melanocytic matricoma appears as a solitary pigmented papule, usually less than 1 cm in diameter. The lesion usually arises on sun-damaged skin, such as the face, scalp, or neck. The back, hand, and forearm are also reported sites. These tumors are generally asymptomatic, but they can sometimes cause discomfort or tenderness.

There are a few reported cases of malignant melanocytic matricoma, all in individuals in the 8th decade or older, and these have a propensity for the head and neck.


D49.9 – Neoplasm of unspecified behavior of unspecified site

816971006 – Melanocytic matricoma

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Differential Diagnosis & Pitfalls

  • Melanoma
  • Pigmented basal cell carcinoma
  • Dermatofibroma
  • Melanocytic nevus
  • Lobular capillary hemangioma
  • Blue nevus
  • Atypical fibroxanthoma
  • Trichoblastoma

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Last Reviewed:06/27/2023
Last Updated:06/28/2023
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Melanocytic matricoma
A medical illustration showing key findings of Melanocytic matricoma
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