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Acquired dermal melanocytosis
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Acquired dermal melanocytosis

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Contributors: Boya Abudu MD, MPH, Susan Burgin MD
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Synopsis

Acquired dermal melanocytosis (ADM) is a rare, benign pigmentary disorder characterized by dark gray or brown macules and patches, most commonly on the face. Other uncommon locations that have been reported include the extremities, back, and trunk.

Onset of facial lesions is usually in late adolescence or early adulthood. Patients with extrafacial ADM have a variable age of onset of pigmentation. While the majority of facial cases occur in female patients of East Asian origin, extrafacial presentation has a more varied sex and ethnic distribution. Patients usually have darker skin phototypes (Fitzpatrick skin phototype III or greater).

The etiology and pathogenesis of ADM is unclear. It is believed that immature dermal melanocytes may be activated by a trigger such as ultraviolet radiation, chronic inflammation, chemical exposure, or excessive sex hormones (ie, estrogen).

Related topic: Congenital dermal melanocytosis

Codes

ICD10CM:
L81.9 – Disorder of pigmentation, unspecified

SNOMEDCT:
414032001 – Disorder of pigmentation

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 06/10/2019
Last Updated: 06/12/2019
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Acquired dermal melanocytosis
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Acquired dermal melanocytosis : Blue color, Brown color, Forehead, Nose, Hyperpigmented macules, Hyperpigmented patches, Cheeks
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