Acral erythema in Child
See also in: Cellulitis DDxAlerts and Notices
Synopsis
Reactions may occur sooner (24 hours to 3 weeks) and more severely with bolus chemotherapy than with low-dose continuous infusion and are usually reproducible with challenge.
Acral erythema may occur as part of a broader eruption, known as toxic erythema of chemotherapy, in which acral and intertriginous areas are involved. It is characterized by a painful erythematous rash, often with associated edema, located on the palms, fingers, and soles, preceded by dysesthesia.
Codes
ICD10CM:L27.1 – Localized skin eruption due to drugs and medicaments taken internally
SNOMEDCT:
238993006 – Acral erythema
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Raynaud phenomenon
- Cellulitis
- Acute contact dermatitis / contact dermatitis (pediatric)
- Burn (see thermal or electrical burn; chemical burns are covered separately, by chemical agent)
- Frostbite
- Erythromelalgia
- Early serum sickness
- Angioedema
- Periungual erythema may be seen with dermatomyositis / juvenile dermatomyositis, systemic lupus erythematosus, human immunodeficiency virus (HIV), and hepatitis C.
- Papular-purpuric gloves and socks syndrome has been reported with parvovirus B19 and cytomegalovirus infection.
- Acute graft-versus-host disease
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:04/09/2018
Last Updated:04/22/2018
Last Updated:04/22/2018
Acral erythema in Child
See also in: Cellulitis DDx