Acropustulosis of infancy, also known as infantile acropustulosis, is a recurrent, self-limited, pruritic, palmoplantar vesiculopustular eruption that usually begins between birth and age 2. Additional reported sites include dorsal hands and feet, wrists, and occasionally, the scalp.

The etiology is not fully elucidated; however, it is thought by some authors to represent a post-scabetic phenomenon.

Acropustulosis of infancy may wax and wane for years with pruritic lesions recurring initially every few weeks, then every few months, with the duration and intensity of episodes diminishing over time, ultimately resolving completely.