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Acute post-streptococcal glomerulonephritis
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Acute post-streptococcal glomerulonephritis

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Contributors: Christine Osborne MD, Catherine Moore MD
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Synopsis

Post-streptococcal glomerulonephritis (PSGN) is the most common cause of nephritic syndrome in children and typically occurs 1-3 weeks after a group A beta hemolytic streptococcal (GAS) pharyngitis or 3-6 weeks after a GAS skin infection. It is thought to be a glomerular immune complex disease leading to complement activation and triggered by specific nephrogenic strains of GAS.
  • The clinical features of PSGN are varied, with a majority of children presenting with asymptomatic hematuria.
  • Common clinical features in symptomatic children include peripheral edema, hypertension, hematuria with characteristic tea- or cola-colored urine, acute kidney injury, and proteinuria, which at times reaches nephrotic levels.
Children typically have a good prognosis with normalization of creatinine, while adults may have residual effects of hypertension, recurrent proteinuria, and abnormal renal function.

Codes

ICD10CM:
N00.9 – Acute nephritic syndrome with unspecified morphologic changes

SNOMEDCT:
68544003 – Acute post-streptococcal glomerulonephritis

Differential Diagnosis & Pitfalls

Best Tests

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References

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Last Updated: 05/05/2016
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Acute post-streptococcal glomerulonephritis
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Acute post-streptococcal glomerulonephritis : Edema, Hematuria, BP increased
Copyright © 2018 VisualDx®. All rights reserved.