Hydrostatic bulla (including edema blister, stasis blister) is a common noninfectious blistering condition. Hydrostatic bullae develop due to the rapid accumulation of interstitial fluid in patients with an acute exacerbation of localized or generalized edema (anasarca). Hydrostatic bullae appear and gradually increase in size over time parallel to fluid retention by the patient. This entity is most commonly observed on dependent areas, typically the lower extremities, of older adults who are hospitalized.
Hydrostatic bullae can be seen in various medical conditions associated with an increase in interstitial fluid, including heart failure, renal disease, hepatic cirrhosis, angioedema, hypoalbuminemia, venous occlusion (thrombosis), and lymphedema, or be caused by ingestion of certain drugs (eg, calcium channel blockers).
ICD10CM: R23.8 – Other skin changes
SNOMEDCT: 403177004 – Acute edema blisters
Differential Diagnosis & Pitfalls
Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.