Acute interstitial nephritis
Patients older than 65 appear to be more susceptible to developing AIN with medication exposures, most commonly to penicillins and cimetidine. Patients may or may not be symptomatic. Symptoms are related to the cause of AIN and to the degree of acute kidney injury. When drug induced, allergic-type symptoms of fever, rash, and eosinophilia may develop. Roughly half of patients with AIN develop oliguria.
AIN often resolves with withdrawal of the precipitating agent, with the degree of reversal in renal function dependent on the length of exposure and the extent of tubular damage.
N12 – Tubulo-interstitial nephritis, not specified as acute or chronic
28637003 – Acute interstitial nephritis
Differential Diagnosis & Pitfalls
Drug Reaction Data