Acute lymphoid leukemia in Infant/Neonate
Diagnosis usually requires the presence of over 20% lymphoblasts in the peripheral blood, and/or the presence of bone marrow or tissue infiltrate of immature cells with confirmation of lymphoid lineage by flow cytometry and/or cytochemistry.
ALL/LBL is the most common cancer in children (mostly under 6 years old and accounting for a quarter of all childhood malignancies) and is also seen in adults (usually over 60 years old). Children may present with unexplained fevers, pallor, hepatosplenomegaly, lymphadenopathy, and/or bleeding and easy bruising. The cause of ALL/LBL is unknown, but it has been associated with ionizing radiation as well as certain genetic abnormalities.
For more information, see OMIM.
C91.00 – Acute lymphoblastic leukemia not having achieved remission
91857003 – Acute lymphoid leukemia, disease
- Acute myeloid leukemia
- Myelodysplastic syndrome causing pancytopenia
- Lymphomas such as marginal zone lymphoma, chronic lymphocytic leukemia, or mantle cell lymphoma presenting with leukocytosis; hairy cell leukemia; Hodgkin lymphoma (similar young adult age group), T-cell lymphomas
- Viral illness (eg, human immunodeficiency virus, infectious mononucleosis)
- Aplastic anemia
Last Updated: 04/22/2019