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Acute lymphoid leukemia in Child
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Acute lymphoid leukemia in Child

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Contributors: Nina Haghi MD, Carla Casulo MD, Paritosh Prasad MD
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Synopsis

Acute lymphoblastic leukemia (ALL) / lymphoblastic lymphoma (LBL), also known as acute lymphocytic leukemia / lymphoma or acute lymphoid leukemia, is a cancer of precursor B-cell, T-cell, or other cell types in which immature lymphoid cells accumulate in blood, bone marrow, or other tissue.

Diagnosis usually requires the presence of over 20% lymphoblasts in the peripheral blood, and/or the presence of bone marrow or tissue infiltrate of immature cells with confirmation of lymphoid lineage by flow cytometry and/or cytochemistry.

ALL/LBL is the most common cancer in children (mostly under 6 years old and accounting for a quarter of all childhood malignancies) and is also seen in adults (usually over 60 years old). Children may present with unexplained fevers, pallor, hepatosplenomegaly, lymphadenopathy, and/or bleeding and easy bruising. The cause of ALL/LBL is unknown, but it has been associated with ionizing radiation as well as certain genetic abnormalities.

For more information, see OMIM.

Codes

ICD10CM:
C91.00 – Acute lymphoblastic leukemia not having achieved remission

SNOMEDCT:
91857003 – Acute lymphoid leukemia, disease

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 03/16/2019
Last Updated: 04/22/2019
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Acute lymphoid leukemia in Child
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Acute lymphoid leukemia : Fatigue, Fever, Hepatosplenomegaly, Skin petechiae, Bone pain, Easy bruising, Lymphadenopathy, Neutropenia, Weight loss, Dyspnea, Anemia, Pallor, Thrombocytopenia
Clinical image of Acute lymphoid leukemia
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