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Potentially life-threatening emergency
Acute meningococcemia in Child
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Potentially life-threatening emergency

Acute meningococcemia in Child

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Contributors: Craig N. Burkhart MD, Dean Morrell MD
Other Resources UpToDate PubMed

Synopsis

Meningococcal disease is a rapidly progressive infection caused by Neisseria meningitides, a gram-negative diplococcus bacterium. Infection begins as a nonspecific viral-like illness that rapidly evolves (within hours) into 1 of 2 main presentations: meningitis or septicemia. Most cases are acquired through exposure to asymptomatic carriers via respiratory droplets. Children aged younger than 5 years and teenagers aged 15-19 are predominantly affected.

Complications of acute meningococcemia include pericarditis / myocarditis, disseminated intravascular coagulation (DIC), meningitis and permanent neurologic sequelae, septic arthritis, osteomyelitis, adrenal hemorrhage (Waterhouse-Friderichsen syndrome), gangrene, and death.

Related topic: Chronic Meningococcemia

Codes

ICD10CM:
A39.2 – Acute meningococcemia

SNOMEDCT:
186365005 – Acute meningococcemia

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Multiple other diseases associated with vascular injury must be differentiated from meningococcal disease. Patients with congenital (clotting defects) or immune (vasculitis) causes of purpura and ecchymoses rarely have cardiovascular compromise. The large ecchymoses of meningococcal disease also tend to be well-defined, superficial, and have overlying necrosis, whereas large ecchymoses associated with clotting factor deficiencies or trauma are usually ill-defined, subcutaneous, and are not associated with necrosis. Nonspecific viral exanthems usually appear after a prodrome of several days, whereas patients with meningococcemia typically develop a rash in less than 24 hours of onset of an acute illness. Petechiae caused by coughing, crying, or vomiting are confined to the distribution of the superior vena cava (head, neck, and chest above the nipple line), whereas petechiae associated with meningococcemia are located over the entire torso and extremities.

Infection
Autoimmune Vasculitis
Toxin/Drug
Hematologic
Physical
  • Petechiae caused by coughing, vomiting, or crying
  • Trauma

Best Tests

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Management Pearls

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Therapy

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References

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Last Updated: 12/14/2018
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Potentially life-threatening emergency
Acute meningococcemia in Child
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Acute meningococcemia : Altered mental state, Headache, Vomiting, Mottled configuration, Ecchymosis, Myalgia, Nuchal rigidity, High fever, WBC elevated
Clinical image of Acute meningococcemia
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