AIDS-associated Kaposi sarcoma - Anogenital in
See also in: Overview,External and Internal Eye,Oral Mucosal LesionAlerts and Notices
Synopsis
The outbreak of KS among young, previously healthy men who have sex with men (MSM) heralded the recognition of AIDS in 1981. AIDS-associated KS is the most common neoplasm in human immunodeficiency virus (HIV)-seropositive patients and is an AIDS-defining illness. This form of KS is primarily seen in the MSM population. About 40% of men with AIDS develop KS. Lesions may worsen during immune reconstitution inflammatory syndrome and may also appear in patients with HIV who have received long-term antiretroviral therapy (ART).
Lesions on the penis are common, and, in rare cases, the lesions may invade and penetrate the periurethral tissue, affecting urinary flow. The lesions are asymptomatic; however, large lesions may become eroded, become painful, and form chronic ulcers.
The introduction of ART dramatically decreased the incidence, morbidity, and mortality of AIDS-associated KS. ART should be considered first-line treatment for AIDS-associated KS.
Codes
ICD10CM:C46.0 – Kaposi's sarcoma of skin
SNOMEDCT:
420524008 – Kaposi's sarcoma associated with AIDS
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Differential Diagnosis & Pitfalls
- Bacillary angiomatosis
- Lobular capillary hemangioma (pyogenic granuloma)
- Angiokeratoma
- Metastatic carcinoma or melanoma
- Pigmented basal cell carcinoma
- Early KS may resemble a large junctional nevus, a port-wine stain, or an ecchymosis.
- Hypertrophic lichen planus
- Syphilis
- Lymphogranuloma venereum
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Last Reviewed:02/27/2019
Last Updated:03/05/2019
Last Updated:03/05/2019
AIDS-associated Kaposi sarcoma - Anogenital in
See also in: Overview,External and Internal Eye,Oral Mucosal Lesion