ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferences
Alaskapox virus
Other Resources UpToDate PubMed

Alaskapox virus

Contributors: Jewell Dinkins MS, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Alaskapox is a newly recognized orthopoxvirus, a double stranded DNA virus that is hypothesized to be enzootic in one or more species of mammals in the interior of Alaska.

Only 2 cases of Alaskapox have been reported, one in 2015 and the other in 2020. Both cases occurred during mid-to-late summer in forested areas near Fairbanks, Alaska, and were self-limited. Both cases began with the appearance of a small superficial ulcer, one appearing on the shoulder area and the other on the upper arm. Associated symptoms and signs included surrounding erythema, fatigue, subjective fever, shoulder pain, and tender axillary adenopathy.

Both patients reported seeing small mammals in the vicinity of their homes. Serologic and viral polymerase chain reaction (PCR) testing of trapped animals in the vicinity proved past and current infection in various species of small mammals, including the northern red-backed vole.

There is currently no evidence of human-to-human transmission.

Codes

ICD10CM:
B08.09 – Other orthopoxvirus infections

SNOMEDCT:
414015000 – Disease caused by Orthopoxvirus

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

  • Smallpox – Presents with a febrile prodrome before the onset of lesions. Characterized as a centrifugally disseminated rash with lesions also often present on the palms and soles. This has been eradicated but remains a bioterrorism threat.
  • Monkeypox – Presents with a febrile prodrome before the onset of lesions. Characterized as a centrifugally disseminated rash with lesions also often present on the palms and soles.
  • Cowpox – Presents with fever with the onset of lesions. Lesions are often localized on the hands, face, and neck due to contact transmission.
  • Rickettsialpox – Presents with a triad of fever, vesicular rash, and eschar.
  • Tanapox – Endemic to equatorial Africa and presents with fever, lethargy, headache, backache, and 1-3 pox lesions.
  • Herpes gladiatorum – Presents as vesicles that classically occur in crops.
  • Vaccinia vaccination – The transfer of smallpox vaccine from the vaccination site to the skin and mucosa due to the tendency to scratch the itchy vaccination site.
  • Orf – Endemic to Europe; lesions occur from contact with livestock.
  • Spider bite

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

References

Subscription Required

Last Reviewed:08/30/2021
Last Updated:09/14/2021
Copyright © 2022 VisualDx®. All rights reserved.
Alaskapox virus
Print  
Alaskapox virus
Copyright © 2022 VisualDx®. All rights reserved.