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Amebic colitis in Adult
Other Resources UpToDate PubMed

Amebic colitis in Adult

Contributors: Neil Mendoza MD, Paritosh Prasad MD
Other Resources UpToDate PubMed


A cause of dysentery due to the parasite Entamoeba histolytica.

The protozoal cyst is transmitted by the fecal-oral route, usually after ingesting contaminated water or food. Following excystation, the organism invades the colon.

The highest risk of infection is in settings with poor sanitation levels and low socio-economic conditions. In the developed setting, men who have sex with men are at increased risk for amebiasis. Patients taking corticosteroids, pregnant patients, malnourished patients, or patients who are very young or old are at risk for severe disease.

The majority of infections are asymptomatic, with the likelihood of invasive disease depending on the strain of histolytica involved and the host characteristics. Patients with invasive disease present with dysentery and may appear systemically ill at presentation. They have loose bloody (either grossly or microscopically) stools with mucus. Abdominal cramps are common, and abdominal pain may be very severe. Fever may be present, but it is not seen in all patients. For most patients, these symptoms develop and worsen over about 3-4 weeks before they present for medical care. Some patients may present with more acute symptoms that may be difficult to differentiate from bacterial dysentery. For other patients, the symptoms may worsen over the course of months.

Complications of amebic colitis include intussusception, perforation, and peritonitis. Rarely, toxic megacolon may occur.

The condition is not typically life-threatening unless the patient is presenting with a rare complication of the disease like necrotizing colitis.

Related topic: Cutaneous amebiasis


A06.2 – Amebic nondysenteric colitis

235747003 – Amebic Colitis

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Differential Diagnosis & Pitfalls

  • Bacterial infection – Stool should be sent for routine culture, testing for Enterohemorrhagic Escherichia coli infection, and testing for Clostridioides difficile colitis.
  • Inflammatory bowel disease (Ulcerative colitis, Crohn disease) – Colonoscopy will reveal typical findings.
  • Ischemic colitis – In the United States, more commonly seen in elderly patients with cardiovascular risk factors.
  • Diverticulitis – Bloody diarrhea is atypical of diverticulitis.

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Last Updated:11/01/2022
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Amebic colitis in Adult
A medical illustration showing key findings of Amebic colitis (Colitis) : Abdominal pain, Bloody diarrhea, Fever, Abdominal cramp, Contaminated food exposure, Contaminated drinking water exposure, Heme+ stool
Imaging Studies image of Amebic colitis - imageId=1926452. Click to open in gallery.
Copyright © 2024 VisualDx®. All rights reserved.