ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferencesView all Images (2)
Amyotrophic lateral sclerosis
Print
Other Resources UpToDate PubMed

Amyotrophic lateral sclerosis

Print Images (2)
Contributors: Andrea Wasilewski MD, Richard L. Barbano MD, PhD
Other Resources UpToDate PubMed

Synopsis

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig disease, is a rapidly progressive degenerative disease characterized by loss of motor neurons. ALS leads to paralysis, respiratory failure, and inevitably results in death. Characteristic findings include muscle atrophy, fasciculations, asymmetric limb weakness, dysarthria, dysphagia, foot drop, dyspnea, and drooling. Presentation is varied and may include findings such as fatigue, muscle cramps, spasticity, neck pain, weight loss, trismus, paralysis, hoarseness, cough, impaired cognition, mood changes, sensory loss, bradypnea, orthostatic hypotension, hypoventilation, hyporeflexia, and hyperreflexia. The majority of cases occur sporadically without family history. Approximately 5%-10% of cases are genetically inherited. ALS is more likely to occur in men with a peak incidence in the fifth to seventh decade of life. Veterans are more likely to develop the disease. There are some familial forms of ALS that are associated with concomitant frontotemporal dementia.

Patients typically survive 2-5 years following diagnosis.

For more information, see OMIM.

Codes

ICD10CM:
G12.21 – Amyotrophic lateral sclerosis

SNOMEDCT:
86044005 – Amyotrophic lateral sclerosis

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

References

Subscription Required

Last Reviewed: 10/29/2018
Last Updated: 09/23/2019
Copyright © 2019 VisualDx®. All rights reserved.
Amyotrophic lateral sclerosis
Print 2 Images
View all Images (2)
(with subscription)
Amyotrophic lateral sclerosis : Drooling, Dysarthria, Fasciculations, Foot drop, Muscle atrophy, Unilateral, Dysphagia, Dyspnea
Copyright © 2019 VisualDx®. All rights reserved.