Angina bullosa hemorrhagica - Oral Mucosal Lesion
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Synopsis

This condition affects men and women equally and typically occurs in adults aged 50-70 years. The pathophysiology of ABH is unclear. While precipitating factors such as hot drinks, inhaled corticosteroids, trauma from an adjacent sharp tooth edge, chewing, or a dental procedure have been reported, around half of patients have no obvious precipitant. Some of the reported cases in the literature have had concomitant hypertension and diabetes mellitus. A few patients with drug-induced or idiopathic thrombocytopenia have been reported to develop ABH-like bullae.
Codes
ICD10CM:S00.522A – Blister (nonthermal) of oral cavity, initial encounter
SNOMEDCT:
235025005 – Traumatic oral hemorrhagic bulla
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Mucous membrane pemphigoid
- Epidermolysis bullosa acquisita
- Erythema multiforme
- Oral amyloidosis (see AL amyloidosis)
- Pemphigus vulgaris
- Dermatitis herpetiformis
- Erosive lichen planus
- Hemorrhagic blisters from low platelets in hematologic disorders such as leukemia
Best Tests
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:11/20/2019
Last Updated:11/20/2019
Last Updated:11/20/2019