Angiolipoma in Adult
Alerts and Notices
SynopsisAngiolipomas are benign soft tissue tumors composed of adipocytes. Clinically, they resemble lipomas, but they may be slightly firmer on palpation. While lipomas are typically asymptomatic, angiolipomas can be tender or painful. Angiolipomas differ from lipomas in their composition because they include vascular and neural elements. Angiolipomas are usually less than 2 cm in size and may be solitary or multiple. They are most commonly found on the forearms, but they may also occur on the trunk or upper arms. Approximately 5% of angiolipomas are familial, most often following an autosomal recessive transmission pattern.
Symptomatic angiolipomas have been noted to appear with the initiation of antiretroviral therapy in HIV patients. This may be associated with fat redistribution that has been observed with protease inhibitors.
Extracutaneous angiolipomas may also occur. They may be found in the kidneys in association with tuberous sclerosis. They account for less than 1% of spinal tumors, in which case they may be associated with spina bifida.
D17.9 – Benign lipomatous neoplasm, unspecified
404057003 – Angiolipoma
Differential Diagnosis & PitfallsLipomas usually are not tender or painful.
- Epidermoid cysts (epidermal inclusion cysts) have a characteristic overlying punctum.
- Blue rubber bleb nevus syndrome
- Dercum disease
- Glomus tumor
- Granular cell tumor
- Hibernoma – These are often large, persistent lipomatous lesions on the neck, back, or axilla. Biopsy is necessary for definitive diagnosis.
- Abscess – One would expect to see accompanying erythema and induration.
- Metastatic malignancy is usually much firmer to the touch.
Drug Reaction DataBelow is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.
Angiolipoma in Adult