Commonly implicated medications include anticholinergics such as benztropine and scopolamine, antihistamines such as meclizine and diphenhydramine, antipsychotics such as clozapine and olanzapine, antispasmodics such as dicyclomine and oxybutynin, cyclic antidepressants such as amitriptyline and imipramine, and mydriatics such as cyclopentolate.
Many plants also have anticholinergic properties, including wild mushrooms, nightshade, and Jimson weed.
Treatment includes supportive care and, in select cases, gastric decontamination and/or antidote treatment with physostigmine salicylate.
T44.3X1A – Poisoning by other parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics, accidental (unintentional), initial encounter
216593002 – Accidental poisoning by anticholinergic
- Neuroleptic malignant syndrome
- Serotonin syndrome
- Drug intoxication (eg, cocaine, amphetamines, ecstasy)
- Alcohol withdrawal
- Benzodiazepine withdrawal
- Central nervous system infection (meningitis [viral, bacterial, fungal], encephalitis)
- Anti-NMDA receptor encephalitis
- Head trauma
- Heat stroke
- Malignant hyperthermia
Last Updated: 03/27/2019