Etiology includes accumulation of calcium in the aortic valve (most common in the elderly population), congenital abnormalities (ie, bicuspid aortic valve), rheumatic fever, chest radiotherapy, endocarditis, alkaptonuria, and familial hypercholesterolemia. Complications include heart failure, cardiac arrhythmias, infectious endocarditis, pulmonary hypertension, excessive bleeding, stroke, and other embolic events.
Treatment for mild cases is symptomatic. Intense physical activity should be limited. More severe cases require surgical repair. However, even mild cases have a 50% increase in 5-year risk of acute coronary syndrome and cardiovascular death. A minority of cases will present with acquired von Willebrand disease that improves with aortic valve replacement.
I35.0 – Nonrheumatic aortic (valve) stenosis
60573004 – Aortic valve stenosis
- Congestive heart failure (systolic)
- Heart failure with preserved ejection fraction
- Supravalvular aortic outflow obstruction – associated with Williams syndrome
- Obstructive hypertrophic cardiomyopathy
- Other valvular disorders – mitral valve stenosis or mitral valve insufficiency, aortic insufficiency
- Endocarditis – see acute bacterial endocarditis
- Acute coronary syndrome
Last Updated: 04/25/2019