Apert syndrome, a type of acrocephalosyndactyly, is a genetic disorder associated with craniosynostosis and premature epiphyseal closure, which results in deformities of the skull, hands, and feet. Most cases are new mutations, but autosomal dominant inheritance can occur. Patients with Apert syndrome have typical appearance with flat facies, flat occiput, brachycephaly, hypertelorism, and syndactyly of the hands and feet. The syndactyly may result in a large single nail. Patients can also have significant acne that may require treatment with isotretinoin.