Aphthous ulcers occur mostly in the mouth but can be present as very painful, relapsing, vulvar ulcers of unknown etiology. Recurrent oral and genital aphthae in the absence of Behçet disease is complex aphthosis. Epstein-Barr virus (EBV) may be associated. In the absence of oral ulcers, complex aphthosis is sometimes called Lipschütz disease. The entity of juvenile gangrenous vasculitis of the scrotum is thought by many authors to be the male counterpart of Lipschütz ulcers. Lipschütz disease may be idiopathic in 90% of cases, and 10% of cases are associated with underlying conditions. The age of onset is typically between 9 and 18 years.
ICD10CM: K12.0 – Recurrent oral aphthae
SNOMEDCT: 426965005 – Aphthous ulcer of mouth
Differential Diagnosis & Pitfalls
Ten percent of vulvar aphthous ulcers are associated with inflammatory bowel disease (, ), , or myeloproliferative diseases.
(mouth and genital ulcers with inflamed cartilage)
Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.