Argyria
See also in: External and Internal Eye,Nail and Distal DigitAlerts and Notices
Synopsis
Argyria refers to the deposition of silver or silver-containing compounds within tissue(s). Argyria may occur locally due to direct contact with silver-containing materials, or as a generalized phenomenon when there is systemic dissemination of the silver. The features of argyria become apparent from 6 months to several years following initial exposure to the product containing silver.
Codes
ICD10CM:
L81.8 – Other specified disorders of pigmentation
SNOMEDCT:
255636009 – Argyria
L81.8 – Other specified disorders of pigmentation
SNOMEDCT:
255636009 – Argyria
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Blue nail changes can also occur with Wilson disease.
- Heavy metals such as mercury, bismuth, arsenic, gold, or lead
- Medications such as minocycline, antimalarials, amiodarone, or phenothiazine
- Ochronosis
- Hemochromatosis
- Addison disease
- Cyanosis
- Pseudomonas infections of the nails
Best Tests
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.
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References
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Last Updated:09/10/2017
Argyria
See also in: External and Internal Eye,Nail and Distal Digit