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See also in: External and Internal Eye,Nail and Distal Digit
Contributors: Michael D. Tharp MD, Neil Shear MD
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Argyria refers to the deposition of silver or silver-containing compounds within tissue(s). Argyria may occur locally due to direct contact with silver-containing materials, or as a generalized phenomenon when there is systemic dissemination of the silver. The features of argyria become apparent from 6 months to several years following initial exposure to the product containing silver.


L81.8 – Other specified disorders of pigmentation

255636009 – Argyria

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Updated:09/11/2017
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