SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferences

View all Images (27)

Autoeczematization in Adult
Other Resources UpToDate PubMed

Autoeczematization in Adult

Contributors: Erin X. Wei MD, Amy Spizuoco DO, Jeffrey D. Bernhard MD, Susan Burgin MD
Other Resources UpToDate PubMed


Id reaction, also known as autoeczematization, secondary dermatitis, autosensitization dermatitis, and generalized eczema, occurs when eczema develops at sites not affected by a primary, inciting dermatosis. In adults, the primary dermatosis is typically allergic contact dermatitis with or without underlying stasis dermatitis, but id reaction is also seen in association with stasis dermatitis without allergic contact dermatitis, other forms of eczematous dermatitis, and inflammatory bullous tinea pedis. The reaction usually appears a few days to weeks after the primary dermatitis and can be severely pruritic. It shows a symmetric distribution and has a predilection for the palms, soles, and extensor surfaces of the upper extremities. All ages and populations, and both sexes, are equally affected.

Autoeczematization is thought to result from a lower threshold for developing an eczematous hypersensitivity reaction in patients with preceding or concurrent inflammatory processes of the skin. Memory T-cells are thought to play a role in the cases of id reaction associated with allergic contact dermatitis. In the case of tinea, id reaction can develop after the institution of effective therapy and can be mistaken for an allergic reaction to the medication.


L30.2 – Cutaneous autosensitization

3014005 – Id reaction

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Differential diagnoses include rashes that can arise in a widespread or disseminated fashion:
  • Atopic dermatitis
  • Contact dermatitis (Allergic contact dermatitis, Irritant contact dermatitis) including airborne and textile dermatitis, or as a reaction to ingested allergens
  • Photoallergic dermatitis (see Allergic contact dermatitis, Drug-induced photoallergic reaction, Phytophotodermatitis)
  • Papular urticaria
  • Papulovesicular Pityriasis rosea
  • Polymorphous light eruption
  • Polymorphic eruption of pregnancy
  • Eczematous drug eruption
  • Cutaneous T-cell lymphoma

Best Tests

Subscription Required

Management Pearls

Subscription Required


Subscription Required


Subscription Required

Last Reviewed:02/03/2021
Last Updated:02/03/2021
Copyright © 2024 VisualDx®. All rights reserved.
Autoeczematization in Adult
A medical illustration showing key findings of Autoeczematization : Erythema, Fine scaly plaque, Scattered many, Pruritus
Clinical image of Autoeczematization - imageId=8915. Click to open in gallery.  caption: 'Widespread coalescing, deep red papules and plaques on the face, chest, and arms.'
Widespread coalescing, deep red papules and plaques on the face, chest, and arms.
Copyright © 2024 VisualDx®. All rights reserved.