Autoimmune progesterone dermatitis
This condition tends to affect women between menarche and menopause but most commonly occurs in their third to fourth decade. It has been reported to occur in the postpartum period and in women undergoing in-vitro fertilization. It has also been reported in the case of a man taking synthetic progesterone. Cases have been reported to either improve or worsen during pregnancy.
Almost all patients experience pruritus. When urticaria predominates, it tends to be generalized in distribution and may be accompanied by laryngospasm. Anaphylaxis may occur. Oral erosions may also be present.
APD usually requires treatment, although the condition has been reported to have resolved spontaneously in several cases.
L30.8 – Other specified dermatitis
838551007 – Autoimmune progesterone dermatitis
Differential Diagnosis & Pitfalls
- Chronic urticaria
- Allergic contact dermatitis
- Erythema multiforme minor (herpes simplex virus-associated erythema multiforme)
- Familial Mediterranean fever
- Hyperimmunoglobulin D with periodic fever syndrome
- TNF receptor-associated periodic syndrome
- Familial cold autoinflammatory syndrome (see cryopyrin-associated periodic syndromes)
- Muckle-Wells syndrome (see cryopyrin-associated periodic syndromes)
- Neonatal-onset multisystem inflammatory disease (see cryopyrin-associated periodic syndromes)
Drug Reaction Data