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Bowenoid papulosis - Anogenital in
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Bowenoid papulosis - Anogenital in

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Contributors: Precious Cebisile Sibisi MBChB, FCDerm, MMed, Anisa Mosam MBChB, MMed, FCDerm, PhD, Ncoza C. Dlova MBChB, FCDerm, PhD, Susan Burgin MD
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Synopsis

Bowenoid papulosis (BP) is a clinical variant of a low-grade squamous cell carcinoma in situ (SCCIS) caused by the human papillomavirus (HPV), usually subtype 16, although other subtypes may occur. Smoking, early sexual initiation, multiple sexual partners, uncircumcised male sexual partners, and immunosuppression are contributory factors.

BP typically occurs in young sexually active adults. There is an equal male-to-female ratio. Lesions are usually asymptomatic and occur primarily in the genital and perianal region.

BP has a variable course, with a frequent potential for spontaneous regression as well as persistence and recurrence. A postsurgical excision recurrence rate of up to 20.3% has also been documented.

The risk of progression to invasive SCC in immunocompetent patients is estimated at 2.6%. In immunocompromised patients, the risk of invasive malignancy may be higher; one-half of human immunodeficiency virus (HIV)-infected patients with anogenital warts have SCCIS on histology.

Codes

ICD10CM:
D04.9 – Carcinoma in situ of skin, unspecified

SNOMEDCT:
402913004 – Bowenoid papulosis

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Last Reviewed: 08/12/2019
Last Updated: 08/16/2019
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Bowenoid papulosis - Anogenital in
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Bowenoid papulosis : Labia majora, Penis, Scrotum, Verrucous scaly papule, Multiple sexual partners
Clinical image of Bowenoid papulosis
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