Bronchiolitis obliterans
Alerts and Notices
Synopsis
Diacetyl is a flavoring compound often used in e-cigarettes / vape pens. Its former use in factories manufacturing microwave popcorn was associated with diagnoses of bronchiolitis obliterans, thus sometimes known as "popcorn lung."
The clinical syndrome manifests as an airway obstruction, cough, and slowly progressive dyspnea (weeks to months), with radiographic examination showing normal or hyperinflation of the lungs. Tachypnea, crackles, and/or wheezing may be evident on physical examination.
Related topic: Bronchiolitis
Codes
ICD10CM:J42 – Unspecified chronic bronchitis
SNOMEDCT:
40100001 – Obliterative bronchiolitis
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Chronic obstructive pulmonary disease (COPD)
- Asthma
- Follicular bronchiolitis
- Interstitial fibrosis
- Hypereosinophilic obliterative bronchiolitis
- Lymphangiomatosis
- Sarcoidosis
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:03/18/2018
Last Updated:01/26/2022
Last Updated:01/26/2022
Bronchiolitis obliterans