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Bullosis diabeticorum
Other Resources UpToDate PubMed

Bullosis diabeticorum

Contributors: John Zampella MD, Noah Craft MD, PhD, Lindy P. Fox MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed

Synopsis

Bullosis diabeticorum (BD), also known as bullous eruption of diabetes mellitus or diabetic bullae, occurs in about 0.5% of diabetic patients and has an unknown pathogenesis. The co-occurrence of neuropathy and nephropathy suggests an underlying microangiopathy. The bullae are noninflammatory and asymptomatic, and they typically develop rapidly.

BD develops in long-standing, uncontrolled diabetic patients, although there are reports of BD as the presenting sign of diabetes. Bullae often resolve on their own without scarring, but recurrence is common, and new bullae can continue to form over a period of years. The average age of onset is 55 years, and there is a 2:1 male-to-female ratio.

Codes

ICD10CM:
E13.628 – Other specified diabetes mellitus with other skin complications

SNOMEDCT:
48951005 – Bullosis diabeticorum

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Differential Diagnosis & Pitfalls

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Therapy

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References

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Last Reviewed:07/29/2019
Last Updated:07/29/2019
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Bullosis diabeticorum
Bullosis diabeticorum : Forearm, Lower leg, Feet or toes
Clinical image of Bullosis diabeticorum
A tense hemorrhagic bulla on the sole, abutting the plantar aspect of the toes.
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