This summary discusses pediatric patients. Bullous impetigo in adults is addressed separately. 

Bullous impetigo is a localized form of staphylococcal scalded skin syndrome caused by exfoliative toxins (A and B) released by (phage group II) Staphylococcus aureus. These toxins cleave desmoglein 1, resulting in superficial blisters locally at the site of infection. It is primarily seen in children, especially infants, who lack antibodies against exfoliative toxins, and only rarely occurs in teenagers or young adults. Infection is spread by direct contact with colonized or infected individuals. Staphylococcus aureus often colonizes the nares, umbilicus, nails, and eyes; approximately 5% of S aureus has exfoliative toxin.

Bullous impetigo initially presents as flaccid bullae, which then rupture, leaving round erosions that become crusted. The disease commonly affects moist intertriginous areas such as the axillae, neck, and diaper area; the face; and the extremities. Constitutional symptoms and fever are rare and mild, if they occur.

In neonates, the infection often presents in the first 2 weeks of life. Full resolution typically occurs within 2-6 weeks. Rare progression to staphylococcal scalded skin syndrome can occur. Sometimes, bullous impetigo may result in serious infections like osteomyelitis, septic arthritis, pneumonia, and septicemia.

Disseminated bullous impetigo has been reported in patients with atopic dermatitis.