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Bullous pemphigoid of childhood in Child
Other Resources UpToDate PubMed

Bullous pemphigoid of childhood in Child

Contributors: Erin X. Wei MD, John Zampella MD, Belinda Tan MD, PhD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

This summary discusses pediatric patients. Bullous pemphigoid in adults is addressed separately.

Bullous pemphigoid is a chronic autoimmune subepidermal vesiculobullous disease that is most common in older adults. It is rarely seen in infants and children, in whom the precise incidence is unknown.

In the pediatric population, clinical presentation of bullous pemphigoid is variable, with ill-appearing patients who have severe, generalized blisters on one end of the spectrum and patients with localized, asymptomatic lesions on the other. As in adults, pruritic urticarial papules and plaques may precede the formation of bullae. Bullae can be widespread or localized on any body surface. In infants, palms and soles may predominate. Mucosal involvement in children is common.

Genital involvement is reported to occur in less than 50% of cases. Localized bullous pemphigoid of the genital skin is reported in children aged 7-12. Girls are affected more frequently than boys. When present, this condition can be misdiagnosed as child sexual abuse, and careful consideration must be taken in these cases.

The natural history of bullous pemphigoid in pediatric patients is not well characterized, but some have been reported to resolve within 1-2 years, while others have had a relapsing course.

Codes

ICD10CM:
L12.0 – Bullous pemphigoid

SNOMEDCT:
402439006 – Childhood bullous pemphigoid

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

For localized genital involvement, also consider: In infants, bullous pemphigoid may involve only the palms and soles and is in the differential diagnosis of all nontransient blistering lesions of childhood.

Best Tests

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Management Pearls

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Therapy

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References

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Last Reviewed:03/01/2022
Last Updated:03/09/2022
Copyright © 2022 VisualDx®. All rights reserved.
Bullous pemphigoid of childhood in Child
A medical illustration showing key findings of Bullous pemphigoid of childhood : Tense bullae, Pruritus, Tense vesicles
Clinical image of Bullous pemphigoid of childhood - imageId=2135869. Click to open in gallery.  caption: 'A bulla and some crusting and hypopigmented macules on the central face.'
A bulla and some crusting and hypopigmented macules on the central face.
Copyright © 2022 VisualDx®. All rights reserved.