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Bullous pemphigoid of childhood in Infant/Neonate
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Bullous pemphigoid of childhood in Infant/Neonate

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Contributors: Craig N. Burkhart MD, Dean Morrell MD, Belinda Tan MD, PhD, Amy Swerdlin MD, Noah Craft MD, PhD
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Synopsis

This summary discusses pediatric patients. Bullous pemphigoid in adults is addressed separately.

Bullous pemphigoid is a chronic autoimmune, subepidermal, vesiculobullous disease that is rarely seen in infants, children, and adolescents (it is most frequently seen in elderly individuals). The disease can occur anywhere, including the oral mucosa. In infants, it may predominate on the palms and soles. In adolescents, it has been reported to resemble adult disease without oral erosions.

On one end of the spectrum, the disease can be severe and generalized, and patients can feel quite ill; on the other end of the spectrum, patients can have a few asymptomatic bullae in localized areas (eg, on the legs). Genital involvement is reported to occur in just under half of cases. Localized bullous pemphigoid of the genital skin is exceedingly rare and is reported in children aged 7-12. Girls are affected more frequently than boys.

In some instances, early bullous pemphigoid lesions will appear as pruritic urticarial papules and plaques.

The condition is often self-limiting, but it can take months to years to resolve.

Codes

ICD10CM:
L12.0 – Bullous pemphigoid

SNOMEDCT:
402439006 – Childhood bullous pemphigoid

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

In infants, bullous pemphigoid may involve only the palms and soles and is in the differential of all non-transient blistering lesions of childhood. Differential diagnosis of localized bullous pemphigoid of the vulva:

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Therapy

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References

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Last Updated: 05/07/2019
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Bullous pemphigoid of childhood in Infant/Neonate
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Bullous pemphigoid of childhood : Tense bullae, Pruritus, Hives , Tense vesicles
Clinical image of Bullous pemphigoid of childhood
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