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Bullous pemphigoid of childhood in Child
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Bullous pemphigoid of childhood in Child

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Contributors: John Zampella MD, Craig N. Burkhart MD, Dean Morrell MD, Belinda Tan MD, PhD, Susan Burgin MD, Amy Swerdlin MD, Noah Craft MD, PhD
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This summary discusses pediatric patients. Bullous pemphigoid in adults is addressed separately.

Bullous pemphigoid is a chronic autoimmune subepidermal vesiculobullous disease that is most common in older adults. It is rarely seen in infants and children, in whom the precise incidence is unknown.

In the pediatric population, clinical presentation of bullous pemphigoid is variable, with ill-appearing patients who have severe, generalized blisters on one end of the spectrum and patients with localized, asymptomatic lesions on the other. As in adults, pruritic urticarial papules and plaques may precede the formation of bullae. Bullae can be widespread or localized on any body surface. In infants, palms and soles may predominate. Mucosal involvement in children is common.

Genital involvement is reported to occur in just under half of cases. Localized bullous pemphigoid of the genital skin is reported in children aged 7-12. Girls are affected more frequently than boys. When present, this condition can be misdiagnosed as child sexual abuse, and careful consideration must be taken in these cases.


L12.0 – Bullous pemphigoid

402439006 – Childhood bullous pemphigoid

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Differential Diagnosis & Pitfalls

For localized genital involvement, also consider: In infants, bullous pemphigoid may involve only the palms and soles and is in the differential diagnosis of all nontransient blistering lesions of childhood.

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Last Reviewed: 08/13/2019
Last Updated: 08/19/2019
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Bullous pemphigoid of childhood in Child
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Bullous pemphigoid of childhood : Tense bullae, Pruritus, Tense vesicles
Clinical image of Bullous pemphigoid of childhood
A bulla and some crusting and hypopigmented macules on the central face.
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