SynopsisCodesDifferential Diagnosis & PitfallsBest TestsReferences
Cardiac sarcoma
Other Resources UpToDate PubMed

Cardiac sarcoma

Contributors: Ryan Hoefen MD, PhD
Other Resources UpToDate PubMed


Cardiac sarcoma is a rare mesenchymal neoplasm or tumor of the heart that is malignant in nature. The most common type is angiosarcoma; other manifestations include rhabdomyosarcomas, leiomyosarcomas, fibrosarcomas, and other variations. Rarely, paragangliomas may occur in the heart. Common signs and symptoms include chest pain, heart murmur, palpitations, dyspnea, night sweats, neck vein distention, weight loss, and swelling of the feet, legs, ankles, or abdomen. Diagnostic determination may be aided by echocardiography, CT, and/or MRI imaging. The malignancy infiltrates cardiac structures rapidly and upon diagnosis may have already begun metastases. Prognosis is generally poor, even with complete resection or cardiac transplant.


C49.9 – Malignant neoplasm of connective and soft tissue, unspecified

424413001 – Sarcoma

Differential Diagnosis & Pitfalls

  • Atrial myxoma
  • Lipomatous hypertrophy of the atrial septum
  • Intracardiac thrombus
  • Cardiac arteriovenous malformation
  • Pericardial cyst

Best Tests

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Last Updated:07/11/2023
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Cardiac sarcoma
A medical illustration showing key findings of Cardiac sarcoma : Chest pain, Night sweats, Heart murmur, Neck vein distension, Heart palpitations, Dyspnea
Copyright © 2023 VisualDx®. All rights reserved.