ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferencesView all Images (7)
Choroidal melanoma - External and Internal Eye
Print
Other Resources UpToDate PubMed

Choroidal melanoma - External and Internal Eye

Print Images (7)
Contributors: Rachel Ellis MD, Andrew Goodfriend MD, Lauren Patty Daskivich MD, MSHS, Brandon D. Ayres MD, Christopher Rapuano MD, Harvey A. Brown MD, Sunir J. Garg MD
Other Resources UpToDate PubMed

Synopsis

Choroidal melanoma, a form of uveal melanoma, is the most common primary intraocular tumor of adults, with an incidence in the United States of 6 cases per million. It is 15 times less common than cutaneous melanoma and mainly affects patients between 60 and 70 years of age. 

Choroidal melanoma is rarely hereditary. The most important risk factors include age, light eye color, fair skin, and chronic sun exposure. Other risk factors include ocular melanocytic conditions such as oculodermal melanocytosis (nevus of Ota) and melanosis oculi. Choroidal nevus, a common benign tumor found on the fundus, may rarely transform to melanoma.

Patients often present without any symptoms, and the choroidal melanoma is found incidentally on routine eye examinations. Patients sometimes complain of blurred vision, floaters, photopsia, or visual field defects.  

Survival rates are generally poor, particularly if metastasis is found. The Collaborative Ocular Melanoma Study (COMS), a large multicenter randomized controlled trial, showed improved survival with younger age and smaller maximum basal tumor diameter. Five-year rates of death with histopathologically confirmed metastasis were 1%, 10%, and 33% for patients found to have, respectively, small (tumors 4-8 mm in largest basal diameter and 1-2.4 mm in thickness), medium-sized (6-12 mm base diameter and 2.5-8 mm thick), and large (greater than 12 mm in largest basal diameter and 8 mm in thickness) ocular melanomas without metastasis at baseline. Chromosomal 3 monosomy also correlates strongly with metastatic disease and mortality. 

Codes

ICD10CM:
C69.30 – Malignant neoplasm of unspecified choroid

SNOMEDCT:
255021005 – Malignant melanoma of choroid

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

  • Choroidal nevus
  • Choroidal hemangioma
  • Metastasis to choroid
  • Combined hemartoma of the retina and retinal pigment epithelium (RPE) 
  • Congenital hypertrophy of the RPE (CHRPE)
  • Melanocytoma 
  • Bilateral diffuse melanocytic proliferation
  • Choroidal osteoma
  • Metastatic carcinoma
  • Hemorrhagic detachment of choroid or RPE (see age-related macular degeneration)

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

References

Subscription Required

Last Updated: 11/21/2013
Copyright © 2019 VisualDx®. All rights reserved.
Choroidal melanoma - External and Internal Eye
Print 7 Images
View all Images (7)
(with subscription)
Choroidal melanoma : Blurred vision, Floaters, Unilateral, Visual field defect, Perceived flashing lights
Clinical image of Choroidal melanoma
Copyright © 2019 VisualDx®. All rights reserved.