Chronic myeloid leukemia in Adult
CML represents about 15%-20% of all leukemias in the United States. Median age at diagnosis is between 50 and 65 years, and there is a slight male predominance.
CML begins in the chronic phase (CP); this may progress to an accelerated phase (AP) and, later, a blast phase (BP), or acute leukemia (> 20% blasts). Approximately 85% of patients will be in CP when they present or are diagnosed.
Related topic: acute myelogenous leukemia
C92.10 – Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission
92818009 – Chronic myeloid leukemia, disease
Differential Diagnosis & Pitfalls
- Leukemoid reaction – reactive nonclonal proliferation of WBC due to infection or stress
- Chronic lymphoid leukemia – increased WBC; however, differential shows they are lymphocytes
- Chronic neutrophilic leukemia – elevated WBC composed of predominantly neutrophils (80%) along with circulating blasts may be associated with mutation in CSF3R, which is a growth factor receptor
- Acute myeloid leukemia – increased WBC made up of > 20% myeloblasts
- Acute lymphoid leukemia – increased WBC made up of > 20% lymphoblasts
Drug Reaction Data