Clear cell acanthoma
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Synopsis

Clear cell acanthoma, also known as pale cell acanthoma, is a benign epidermal tumor presenting as an erythematous papule or nodule with peripheral wafer-like scale, usually found on the leg.
Pathogenesis is unknown, but some have proposed that it is a variant of a seborrheic keratosis, while others favor a reactive inflammatory dermatosis.
Clear cell acanthoma occurs equally in both sexes and has a peak incidence in the 50- to 70-year age range.
Lesions tend to develop over the course of several years, but rarely an eruptive form may occur.
Pathogenesis is unknown, but some have proposed that it is a variant of a seborrheic keratosis, while others favor a reactive inflammatory dermatosis.
Clear cell acanthoma occurs equally in both sexes and has a peak incidence in the 50- to 70-year age range.
Lesions tend to develop over the course of several years, but rarely an eruptive form may occur.
Codes
ICD10CM:
D23.70 – Other benign neoplasm of skin of unspecified lower limb, including hip
SNOMEDCT:
254670002 – Clear cell acanthoma
D23.70 – Other benign neoplasm of skin of unspecified lower limb, including hip
SNOMEDCT:
254670002 – Clear cell acanthoma
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Differential Diagnosis & Pitfalls
- Lobular capillary hemangioma (pyogenic granuloma)
- Dermatofibroma
- Lichenoid keratosis
- Wart
- Basal cell carcinoma
- Squamous cell carcinoma
- Bowen disease
- Amelanotic melanoma
- Inflamed seborrheic keratosis
- Traumatized hemangioma
- Psoriasis
- Eczema
- Nipple eczema
- Paget disease
- Erosive adenomatosis of the nipple (papillary adenoma)
- Benign Toker cell hyperplasia
- Hyperkeratosis of nipple and areola
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Last Reviewed:02/05/2018
Last Updated:02/06/2018
Last Updated:02/06/2018