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Collagenous gastritis
Other Resources UpToDate PubMed

Collagenous gastritis

Contributors: Abhijeet Waghray MD, Desiree Rivera-Nieves MD, Khaled Bittar MD, Nishant H. Patel MD, Paritosh Prasad MD
Other Resources UpToDate PubMed


Collagenous gastritis is an exceedingly rare gastrointestinal disorder characterized by atypical gastric mucosa with an inflamed or nodular appearance. Histologic analysis reveals an irregular thickened collagenous subepithelial band, dilated entrapped capillaries, and intraepithelial inflammatory cells. This disease is very rare, with only 60 reported cases in the medical literature, based on which it is divided into pediatric-onset and adult-onset phenotypes.

Pediatric-onset collagenous gastritis – Presents with abdominal pain and severe anemia with an inflamed and/or nodular stomach and normal-appearing colon. There is no known etiology.

Adult-onset collagenous gastritis – Associated with collagenous colitis and presents with voluminous nonbloody diarrhea. Etiology is possibly secondary to autoimmune, infectious, and medication-induced causes.

Esophagogastroduodenoscopy (EGD) is important for diagnosis and to rule out other causes of symptoms.


K52.9 – Noninfective gastroenteritis and colitis, unspecified

711499009 – Collagenous gastritis

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Differential Diagnosis & Pitfalls

  • Acute Gastroenteritis
  • Viral gastroenteritis
  • Inflammatory bowel disease (eg, Ulcerative colitis)
  • Crohn disease
  • Peptic ulcer disease
  • Food protein-induced enterocolitis syndrome
  • Helicobacter pylori infection
  • Cholangitis
  • Hepatitis (eg, Hepatitis A virus infection, Hepatitis B virus infection, Hepatitis C virus infection)
  • Biliary obstruction
  • Acute Acute cholecystitis
  • Biliary calculus
  • Acute pancreatitis
  • Chronic pancreatitis
  • Pancreatic carcinoma
  • Lymphoma
  • Gastric cancer

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Last Reviewed:12/17/2017
Last Updated:12/17/2017
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Collagenous gastritis
A medical illustration showing key findings of Collagenous gastritis (Adult) : Diarrhea, Epigastric pain, IgG elevated, Hematochezia, Dyspepsia
Copyright © 2024 VisualDx®. All rights reserved.