The prognosis depends on both the age of the patient and stage of disease. There have been reports of patients with stage IV disease differentiating spontaneously to neural ganglion cells with subsequent regression without treatment.
C47.9 – Malignant neoplasm of peripheral nerves and autonomic nervous system, unspecified
432328008 – Neuroblastoma
Differential Diagnosis & Pitfalls
- Congenital rubella and cytomegalovirus (CMV) each can cause "blueberry muffin" spots that can look similar to the papules and nodules of neuroblastoma. Rubella and CMV would have other findings of microcephaly, intrauterine growth retardation, chorioretinitis, and petechiae.
- Congenital leukemia or acute myelomonocytic leukemia
- Neonatal lupus erythematosus
- Neonatal bacterial sepsis
- Enteroviral infection
- Newborn thrombocytopenic purpura
- Congenital syphilis – Scaly papules and skeletal abnormalities.
- Neonatal herpes simplex virus
- Epstein-Barr virus (EBV) infection
- Wiskott-Aldrich syndrome (petechial)