Connective tissue nevi in Infant/Neonate
CTN may be isolated or occur as part of a syndrome, such as tuberous sclerosis (collagenomas known as shagreen patches and fibrous forehead plaque), familial cutaneous collagenomas, Proteus syndrome (cerebriform connective tissue nevus), and Buschke-Ollendorff syndrome (elastomas known as dermatofibrosis lenticularis disseminata). Acquired collagenoma (athlete's nodules) may occur at sites of sporting injuries, such as the feet, knuckles, or knees.
CTN have a variable clinical appearance. They may appear as skin-colored, light brown, or yellowish papules or plaques with a smooth, cobblestone, or peau d'orange surface.
D23.9 – Other benign neoplasm of skin, unspecified
400091006 – Connective tissue nevus of skin
Differential Diagnosis & Pitfalls
- Juvenile fibromatosis
- Fibrous hamartoma of infancy
- Infantile myofibromatosis
- Mastocytoma – Will urticate when stroked.
- Lipoma – Typically softer than CTN.
- Pseudoxanthoma elasticum
- Nevus sebaceus
- Nevus lipomatosis
- Verruciform xanthoma
- See differential diagnosis of collagenoma above.
- Eruptive vellus hair cysts
- Osteoma cutis
- Calcinosis cutis