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Corticobasal syndrome
Other Resources UpToDate PubMed

Corticobasal syndrome

Contributors: Jamie Adams MD, Richard L. Barbano MD, PhD
Other Resources UpToDate PubMed


Corticobasal syndrome, also known as corticobasal ganglionic degeneration, is a rare neurodegenerative disorder characterized by progressive movement and cognitive dysfunction. Symptoms are often asymmetric at onset and include parkinsonism (bradykinesia and rigidity), dystonia, myoclonus, apraxia, aphasia, and/or alien limb syndrome. Patients may also present with cognitive, behavioral, or language changes. Typical age of onset is 45-70, and average duration is 6-8 years.

Early on, this disease may be hard to differentiate from other dementias or parkinsonian disorders. There can be clinical overlap with progressive supranuclear palsy and frontotemporal dementias.


G31.85 – Corticobasal degeneration

18842008 – Corticobasal degeneration

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Parkinson disease
  • Progressive supranuclear palsy
  • Dementia with Lewy bodies
  • Frontotemporal lobar degeneration
  • Alzheimer disease
  • Dementia
  • Normal pressure hydrocephalus
  • Creutzfeldt-Jakob disease
  • Paraneoplastic encephalomyelitis
  • Huntington disease
  • Multiple system atrophy
  • Parkinsonism
  • Whipple disease
  • Wilson disease
  • Neuroacanthocytosis
  • Tertiary syphilis
  • Vitamin B12 deficiency
  • Human immunodeficiency virus disease / Acquired immune deficiency syndrome dementia
  • Carbon monoxide poisoning

Best Tests

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Management Pearls

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Last Reviewed:07/08/2018
Last Updated:02/06/2020
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Corticobasal syndrome
A medical illustration showing key findings of Corticobasal syndrome : Aphasia, Babinski sign, Dystonia, Hyperreflexia, Apraxia, Myoclonus, Depression
Copyright © 2024 VisualDx®. All rights reserved.