Crohn disease - Anogenital in
Symptoms from Crohn disease can vary considerably, both due to location but also to the severity of disease involvement. Patients may present with abdominal pain, bloody or nonbloody diarrhea, weight loss or malnutrition, fistulas, abscesses (often perianal), dysphagia, or oral ulcerations. Additionally, Crohn disease has many extraintestinal manifestations that can at times be the presenting symptoms. These manifestations can involve joints, skin, eyes, vasculature, the lungs, or the kidneys.
Crohn disease may involve the vulva and groin in 22%-44% of cases, either primarily or secondarily. Granulomatous infiltration of genital skin may compress lymphatics, leading to lymphedema of the vulva. Linear ulceration or aphthae may be present. True fistulas may occur. Hidradenitis suppurativa may be associated.
Crohn disease presents most typically in the second to fourth decades of life, with a slight female predominance. While no clear genetic mutation is linked to the development of Crohn disease, there are many genetic mutations that are associated with Crohn disease. For unclear reasons, Crohn disease is more prevalent at higher latitudes and in certain patient populations, namely individuals of Ashkenazi Jewish descent and individuals of Northern European descent in the United States.
K50.918 – Crohn's disease, unspecified, with other complication
34000006 – Crohn's disease
- Behçet disease
- Pyoderma gangrenosum
- Cutaneous sarcoidosis
- Lymphogranuloma venereum
- Hidradenitis suppurativa – May present with firm or fluctuant, tender abscesses and cysts, often with extensive scars and sinus tracking under the surface of the skin. These sinus tracts may drain pus, which is often malodorous.
- Granuloma inguinale