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Emergency: requires immediate attention
Cryptogenic organizing pneumonia
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Emergency: requires immediate attention

Cryptogenic organizing pneumonia

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Contributors: Christine Osborne MD, Ryan R. Walsh MD, Joshua J. Jarvis MD, Alastair Moore MD, Mary Anne Morgan MD
Other Resources UpToDate PubMed

Synopsis

Formerly known as bronchiolitis obliterans organizing pneumonia (BOOP), cryptogenic organizing pneumonia (COP) is a diffuse interstitial lung disease affecting distal and respiratory bronchioles and alveolar ducts and walls. Usually presents in the fifth to sixth decades of life, with men and women equally affected, and is frequently heralded by a flu-like illness.

Patients typically present with relatively short duration of symptoms (weeks to months) including a persistent nonproductive cough, dyspnea, fever, malaise, and weight loss. Physical examination reveals inspiratory crackles in a majority of patients, and radiographic findings include peripheral, patchy bilateral opacities.

History of stigmata of extrapulmonary connective tissue disease and/or medication exposure should be sought to differentiate COP from other idiopathic interstitial pneumonitides.

Codes

ICD10CM:
J84.116 – Cryptogenic organizing pneumonia

SNOMEDCT:
129458007  – Bronchiolitis obliterans organizing pneumonia

Look For

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Differential Diagnosis & Pitfalls

Best Tests

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 09/19/2016
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Emergency: requires immediate attention
Cryptogenic organizing pneumonia
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View all Images (6)
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Cryptogenic organizing pneumonia : Cough, Fever, Hypoxemia, Malaise, Weight loss, Dyspnea, Hypoxia
Imaging Studies image of Cryptogenic organizing pneumonia
Reverse halo/atoll sign within the right upper lobe and superior segment of the right lower lobe, with peripheral dense airspace and central areas of ground glass attenuation. Some additional areas of ground glass and airspace opacities, and patchy airspace disease with the right middle lobe, with traction bronchiectasis and architectural distortion.
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