Pathogenic forms of Entamoeba histolytica cause cutaneous amebiasis, which usually results from direct extension of intestinal amebiasis. Involvement of the female genitals occurs by extension of rectal amebiasis. Colonic surgery on the involved amebic colon, hepatic amebiasis, and direct inoculation are also routes for skin involvement.

In general, cutaneous disease commonly presents as one or more painful ulcers that can become necrotic. Notably, ulcers tend to enlarge rapidly. If left untreated, progression is rapid and massive destruction of skin and subcutaneous tissues may ensue.